Autosomal Dominant Polycystic Kidney Disease in Cats-PKD1

The animal health trust DNA service offers a test for Autosomal Dominant Polycystic Kidney Disease in Cats-PKD1

What is it?

Autosomal dominant polycystic kidney disease is a genetic disease occurring in Persian and in Exotic Short-hair cats but which has also spread to other breeds, such as the British Short-hair.

The disease is characterised by renal failure.

What causes it?

The mutation, or change to the structure of the gene, probably occurred spontaneously in a single cat but once in the population has been inherited from generation to generation as any other gene. The mutation causing this disease has been identified in a gene called PKD1 by a research group at the University of California led by Dr Lesley Lyons.

The disease is inherited with a dominant mode of inheritance. All cats have two copies of the PKD1 gene, one inherited from each parent. If either of these copies is the mutant form of the gene, then the cat will be affected with the disease. The affected cat will also pass on a copy of the mutant gene to, on average, 50% of its offspring, which will in turn be affected by the disease.

We now offer a DNA test for this disease which directly detects the mutation.

This test is an alternative to ultrasound scanning.

How do I order?

The test requires 1ml EDTA blood sample and costs £40 + VAT.

This test cannot be ordered online. The test form should be downloaded and completed when the vet collects the blood sample.

The testing form, sample and a cheque for the test cost should then be returned to the address given on the form.

Our DNA testing form can be downloaded by clicking here.