Neonatal Cerebellar Cortical Degeneration

BUY NOW >>Neonatal Cerebellar cortical degeneration (NCCD) is a hereditary disease that can affect beagle puppies. In 2012 Veterinary Neurologists and scientists from the Kennel Club genetics centre at the Animal Health Trust identified the mutation causing this disease and made a DNA test available.

Puppies affected by Neonatal Cerebellar Cortical Degeneration (NCCD) start showing clinical signs at around 3 weeks of age. They are slower and less coordinated than litter mates; they will fall more often and will not be able to regulate a normal gait.

This disease has minimal progression but at present there is no cure. The clinical signs are due to damage in the cerebellum, the part of the nervous system controlling movement and equilibrium.

How is the disease inherited?

This disease shows an autosomal recessive mode of inheritance. Which means that two copies of the mutation, one form each parent, are required for the dog to be affected with NCCD.

Dogs that have one copy of the mutation and one copy of the normal gene are called carriers. These dogs do not develop this disease, but can pass this on to their offspring.

In all cases the terms “normal” and “mutation” refer to the position in the DNA where the NCCD mutation is located. It is not possible to learn anything about any other region of DNA from the NCCD DNA test.

Owners will receive one of the three results detailed below

Clear: The dog has two copies of the normal gene and will not develop NCCD as a result of this mutation.

Carrier: The dog has one copy of the mutation and one copy of the normal gene. The dog will not develop NCCD as a result of the mutation but can pass this on to their offspring.

Affected: The dog has two copies of the mutation and will be affected by NCCD.

Please note that we cannot exclude the possibility that they develop a clinically similar but genetically unrelated disorder due to other mutations.

Breeding advice

Dogs carrying this mutation can still be breed to clear dogs.  Such a mating will on average results in 50% of the puppies being clear of this mutation  and 50% that are carriers of this mutation. Pups that will be used for breeding should then be DNA tested themselves to determine if they are carriers of clear.

Clubs/associations receiving results

Results from this test are reported directly to the Kennel Club.

Results are only reported to clubs and associations within the country of residence given when ordering.

For more information please contact us and we’ll be happy to deal with your enquiry.