Neuronal Ceroid Lipofuscinosis (NCL)

BUY NOW >> Neuronal Ceroid lipofuscinosis is a lysosomal storage disease that occurs due to a hereditary metabolic defect. This disorder causes a build up of ceroid lipofuscin. This build up affects the brain and eyes of the dogs.

How is the disease inherited?

Border CollieWhen two carriers are crossed, 25% (on average) of the offspring will be affected by the disease, 25% will be clear and the remaining 50% will themselves be carriers.

Breeders using our  DNA test will be sent results identifying their dog as belonging to one of three categories.  In all cases the terms ‘normal’ and ‘mutation’ refer to the position in the DNA where the mutation causing Neuronal Ceriod Lipofuscinosis is located in the Border Collie it is not possible to learn anything about any other region of DNA from this  test.

 

 

CLEAR: these dogs have two normal copies of DNA. Clear dogs will not develop Neuronal Ceriod Lipofuscinosis as a result of  this mutation.

CARRIER: these dogs have one copy of the mutation and one normal copy of DNA. These dogs will not develop Neuronal Ceriod Lipofuscinosis themselves as a result of this mutation but they will pass the mutation on to approximately 50% of their offspring.

GENETICALLY AFFECTED:these dogs have two copies of this retinopathy mutation and are very likely to develop Neuronal Ceriod Lipofuscinosis during their lifetime.

We cannot exclude the possibility that the tested dog may develop another similar condition due to other mutations they might carry that are not detected by this test

Breeding advice

Carriers can still be bred to clear dogs. On average, 50% of such a litter will be clear and 50% carriers; there can be no affected dogs produced from such a mating.

Pups which will be used for breeding can themselves be DNA tested to determine whether they are clear or carriers of SN.

For more information please contact us and we’ll be happy to deal with your enquiry.

Please note that we are unable to accept samples from the US or Australia for this test.